Abstract
Fortunilides M-O (1–3), three new lindenane-type sesquiterpenoid dimers, together with eighteen known dimers (4–21), were isolated from the roots of Chloranthus fortunei. The structures were determined by their NMR, HRESIMS, ECD data and quantum chemical calculations. All compounds were classical [4 + 2] lindenane-type sesquiterpenoid dimers, in which compounds 2–4 and 16–17 had rare additional carbon‑carbon link between C-11 and C-7′. Their anti-inflammatory activity in LPS-induced RAW 264.7 and BV2 microglial cells were screened, and compounds 9 (IC50: 10.70 ± 0.25 μM) and 2 (IC50: 12.26 ± 2.43 μM) showed significant effect, respectively.
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