Abstract
Self-nano-emulsifying drug delivery systems (SNEDDS) have gained attention in recent years as an effective approach for improving the solubility and oral bioavailability of poorly water-soluble drugs. However, there have been reports of drawbacks such as low drug loading, limited stability and variability in absorption. Various technologies have been investigated in conjunction with SNEDDS to alleviate such issues such as polymers being used to improve stability and drug loading; phospholipid complexes used to improve absorption and reduce inter and intrasubject variability; SNEDDS for drug targeting improves the targeting of drugs to specific site reducing the dosage required for action. 3D printing is used to create personalized and precise dosages; supersaturated SNEDDS is used to increase drug concentration; and solid SNEDDS are used to improve storage stability and patient compliance. The amalgamation of SNEDDS with these technologies has demonstrated promising results with regard to the improvement of medication delivery and has control over SNEDDS limitations. The present review elucidates the application of blended technologies with SNEDDS and the future potential for such drug delivery.
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