Abstract
ACTH treatment of bovine adrenocortical cells in primary culture causes increased accumulation of mRNAs encoding cytochromes P-450scc, P-45011β, P-45017α, P-450C21 and adrenodoxin as well as increased transcriptional activity of their respective genes. In this study we have shown that ACTH does not greatly affect the half-life of mRNAs encoding P-45011β, P-45017α, P-450C21 and adrenodoxin. However, in the case of P-450scc mRNA, ACTH causes a five-fold increase in the half-life leading to a significant stabilization of P450scc mRNA. Thus it appears that the levels of mRNAs encoding P-45011β, P-45017α, P-450C21 and adrenodoxin are regulated by ACTH primarily at the transcriptional level, while that for P-450scc is regulated at both the transcriptional and post-transcriptional levels.
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