Abstract
In general there are two therapeutic strategies for advanced vulvar cancer: operation and primary chemoradiotherapy. These modalities differ especially in their complications. The most important criterion for the choice of the preferred therapeutic approach is the possibility of operation with free margins and without resulting stomata. Otherwise primary chemoradiotherapy should be preferred. Radiation is performed as external beam on the vulva, groins and pelvis. It is combined synchronously with a chemotherapy with 5-FU in combination with cisplatin or mitomycin-C. The decision on the therapeutic concept is interdisciplinary, with the participation of radiooncologists and gynaecologic oncologists.
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