Abstract
This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the diagnostic test accuracy of Forns index and 'FIB4' in diagnosing people with chronic hepatitis C virus, using liver biopsy as the reference standard. To compare the diagnostic accuracy of the pre-defined cut-off values, used in the original publications, versus the accuracy of other published cut-off values, used in the included studies. To compare the diagnostic accuracy of Forns index and 'FIB4' in people with chronic hepatitis C. To explore potential sources of heterogeneity: serum levels of alanine transferase activity (Dufour 2000); different levels of inflammation according to liver biopsy; different quality of liver biopsy sample (based on length and number of portal tracts); people with and without HIV co-infection; studies with high methodological quality compared to studies with low or unclear methodological quality, applying the QUADAS-2 tool (Whiting 2011). serum levels of alanine transferase activity (Dufour 2000); different levels of inflammation according to liver biopsy; different quality of liver biopsy sample (based on length and number of portal tracts); people with and without HIV co-infection; studies with high methodological quality compared to studies with low or unclear methodological quality, applying the QUADAS-2 tool (Whiting 2011).
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