Abstract
After a successfully identified and synthesized Polydimethylsiloxane is known as silicone oil, the product needs to be upgraded and reformulated into a scalable dosage form. The scale-up in the production of silicone oil is very important in order to prepare the fabrication of silicone oil in large quantities. Here, we reported the synthesis of silicone oil using a duplicated scale to produce silicone oil of the same target quality as a laboratory scale. The dosage was increased twice compared to the previous report. The scale-up of silicone oil samples with viscosity values of 1700 - 2920 mPa.s has been successfully synthesized from Octamethylcyclotetrasiloxane (D4) as monomer and Hexamethyldisiloxane (MM) as terminator using ring-opening polymerization method. From FTIR spectroscopy, it was found that all the samples synthesized with double dosage had a structure and functional groups similar to commercial PDMS. From the refractometer and surfgauge measurements, the scale-up sample has a refractive index in between 1.4026 and 1.4038 and a surface tension value from 19.0 to 20.0 m.N/m.
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