Abstract
The present paper aims at creating a pharmaceutical formulation, i.e. microemulsion with capsaicin as the active principle; the purpose was to solubilize capsaicin and draw up pseudoternary phase diagrams establishing the microemulsion domains. We created a pharmaceutical form: capsaicin ointment, aiming at releasing capsaicin in the microemulsion and ointment bases. Comparative microbiological determinations were performed between microemulsion and ointment. The novelty of the study is formulating microemulsions as a means of solving solubility issues and increasing the bioavailability of medicinal substances.
Highlights
The present paper aims at creating a pharmaceutical formulation, i.e. microemulsion with capsaicin as the active principle; the purpose was to solubilize capsaicin and draw up pseudoternary phase diagrams establishing the microemulsion domains
Administering capsaicin attracts the cells of the immune system that help destroy bacteria making it useful in antibiotic-resistant infections, and inactivating toxic substances issued from cellular destruction and adverse allergic and non-allergic reactions, the potential adverse effects of common drugs being well-known in medical practice of various specialties [9-21] A study performed in India showed that a diet rich in spices and chilli peppers and low in proteins leads to good results in decreasing body weight and normalizing triglycerides in the body
In order to prepare the capsaicin microemulsion we drew up the phase pseudoternary diagrams by means of which the mixture ratios were found
Summary
The present paper aims at creating a pharmaceutical formulation, i.e. microemulsion with capsaicin as the active principle; the purpose was to solubilize capsaicin and draw up pseudoternary phase diagrams establishing the microemulsion domains. The purpose of the paper is the answer to an urgent need of today ’s scientific community, i.e. applying nanotechnologies to medicine functionalization In this respect, we aimed at including capsaicin in stable nanostructured thermodynamic systems of the microemulsion (nanoemulsion) type, in order to obtain a pharmaceutical form with potential topical application. Capsaicin introduced in the blood stream through gel as a pharmaceutical formula plays a part in reducing internal bleeding, healing gastro-duodenal ulcers and protecting against haemorrhagic strokes[8].Studies carried out at Harvard University indicate the use of capsaicin in treating neuropathic pain in post herpetic neuralgia It may be used for atypical facial pain (caused by the irritation of the trigeminal nerve innervating the face area). Administering capsaicin attracts the cells of the immune system that help destroy bacteria making it useful in antibiotic-resistant infections, and inactivating toxic substances issued from cellular destruction and adverse allergic and non-allergic reactions, the potential adverse effects of common drugs being well-known in medical practice of various specialties [9-21] A study performed in India showed that a diet rich in spices and chilli peppers (with high capsaicin levels) and low in proteins leads to good results in decreasing body weight and normalizing triglycerides in the body
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