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Abstract
Aim: Ivabradine hydrochloride is a hyperpolarized activated channel blocker used for symptomatic treatment of chronic angina pectoris. However, due to its short half-life it is rapidly eliminated from systemic circulation. Materials & methods: Floating in situ gel was formulated using sodium alginate and HPMC K 100M by pH induced ion gelation technique employing 32 factorial design for optimization and evaluated. Results: The in situ formulation remained buoyant in gastric environment for 12h. Optimized formulation sustained and prolonged drug release in comparison withmarketed product. Kinetic analysis of drug release indicated non fickian mechanism. Short term stability studies showed no significant changes indicating good formulation stability. Conclusion: Formulated in situ solution shows potential effective sustained release over a prolonged period of time.
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