FORMULATION OPTIMIZATION AND EVALUATION OF TINIDAZOLE IN-SITU

Yaduwanshi Payal,Goswami Anindya,Malviya Neelesh

doi:10.32553/jbpr.v10i2.856

Abstract

The study deals with formulation optimization and evaluation of tinidazole gel by using sodium alginate as gelling agent calcium chloride, sodium citrate were used as cross linking agent. The polymeric solution of drug is in solution form before it administered to the body. But after administration when it comes in contact with acidic pH it’s converted into gel form and the drug tinidazole released from the dosage form constantly and slowly. The formulation is effective for the treatment of gastric ulcer because of Helicobacter pylori. 32 full factorial design were used for the optimization of the formulation 12 trial batches were prepared and 9 factorial design batches in which 2 factor 3 level factorial design were used for the optimization. The concentration of sodium alginate, were taken in 3 level low, medium, high and the prepared formulation were evaluated.

Highlights

Helicobacter pylori (H. pylori) are reported to be an important etiologic factor in the development of the gastritis, gastric ulcer and gastric carcinoma in human stomach
The study deals with formulation optimization and evaluation of tinidazole gel by using sodium alginate as gelling agent calcium chloride, sodium citrate were used as cross linking agent
The formulation is effective for the treatment of gastric ulcer because of Helicobacter pylori. 32 full factorial design were used for the optimization of the formulation 12 trial batches were prepared and 9 factorial design batches in which 2 factor 3 level factorial design were used for the optimization

Summary

Introduction

Helicobacter pylori (H. pylori) are reported to be an important etiologic factor in the development of the gastritis, gastric ulcer and gastric carcinoma in human stomach. H. pylori are accepted as a cause of chronic active gastritis and are intimately associated with peptic ulcer disease. The gel is defined as a soft, or semi-solid or solid like material, which has both solid and liquid component, where the solid component present as a mesh/network of aggregates, which immobilizes the liquid component. This solid network prevents the liquid from flowing by increasing the surface tension[3].In situ gels are an excellent formulation for several routes of administration. They are helpful as fluid definition in oral, effective, vaginal, and rectal organization [4]

Methods

Results

Discussion

Conclusion