Abstract
The aim of present study is to prepare microspheres of eudragit RL 100 loaded with Nefopam Hydrochloride by single emulsion solvent evaporation technique. Taguchi L9 orthogonal array design has been used to optimize the composition and operating conditions for preparation of formulations. Nine batches (F1-F9) were prepared by taking three independent variables (X 1 - drug: polymer ratio, X 2 - stirring speed and X 3 - stirring time) at three levels (+1, 0, -1). Response variables studied for batches (F1-F9) were mean particle size (µm) (Y 1 ), drug entrapment efficiency (% w/w) (Y 2 ) and drug loading (% w/w) (Y 3 ). Drug- polymer compatibility study was carried out by DSC and FTIR spectroscopy and indicates no physicochemical interaction. Microspheres were analyzed for morphological characteristics, mean particle size, drug entrapment efficiency, drug loading and in-vitro drug release. Percentage cumulative drug release for optimized batch F5 was found to be 85.421 ± 0.054 and followed higuchi model for release of drug.
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