Formulation, optimization and evaluation of losartan potassium microemulsions for treating hypertension

Abstract

Microemulsions are the advanced form of the conventionally used emulsions, which is a biphasic dosage form consisting of two immiscible liquids that are brought together with the application of surfactants and cosurfactants. The micron sized globules of microemulsions helps in achieving targeted action with improved availability and stability. The studies related to the microemulsions concluded its potential in delivering various hydrophilic and lipophilic drugs and several leading manufacturers are considering this as ideal formulation for delivering several potent drugs via several routes including oral, ocular, parenteral, topical routes. The advancements occurred during the previous few years in the pharmaceutical sector results in identification of innovative methods for preparing microemulsions and various patents related to the preparation of microemulsions are granted during last decade. This article enlisted the basic information related to the microemulsion along with its component, structure, method of preparation and evaluation parameters. The applications of microemulsion in several sectors of healthcare segment are also discussed in this review and the future scenario is also discussed in the article. Along with this, the article also enlisted the commercially available microemulsion, patent insight of microemulsion and the list of drugs previously used by the researchers for preparing microemulsion based products.