FORMULATION, OPTIMISATION AND CHARACTERISATION OF ARTOCARPUS ALTILIS LOADED LIPOSOMES FOR ANTIDIABETIC ACTIVITY

Abstract

Background: Artocarpus altilis primarily comprises phenolic phytoconstituents such as flavonoids, arylbenzofurans, and stilbenoids. This plant has traditionally been known to have glycemic control properties. This study used a design expert approach to create and test Artocarpus altilis liposomes for antidiabetic activity. Methods: Design Expert 13 software developed and optimised the liposomal formulation. The optimised formulation was tested for antidiabetic properties in a Streptozotocin-nicotinamide-induced model for 28 days, followed by an oral glucose tolerance test. Biochemical parameters such as lipid profile and glycogen content were also measured at the end of the study. Results: The formation of Artocarpus altilis loaded liposomes was confirmed by SEM analysis and entrapment efficiency. Further pharmacology research revealed that Artocarpus altilis lowers blood glucose levels by sensitising insulin secretion, maintaining pancreatic beta cell mass, increasing glucose uptake in skeletal muscles, and regulating lipid profiles. Conclusion: The current study reflected the formulation of Artocarpus altilis loaded liposomes, its entrapment efficiency, stability study, and its antidiabetic evaluation based on in vivo results.