Abstract
The effects of some formulation variables on the release rates of promethazine hydrochloride from hydroxypropylmethylcellulose (HPMC) tablet matrices have been investigated. The major controlling factor appeared to be the promethazine: HPMC ratio and a straight-line relationship existed between the Higuchi-type release rate and the reciprocal of the tablet content of HPMC. Increasing the particle size range of promethazine from 45–63 to 500–700 μm only produced a 12% increase in the drug release rate. Variation in compaction pressure from 93 to 1395 MNm −2 and the absence or presence of 0.75% magnesium stearate as lubricant appeared not to modify release rates. The lowest viscosity grade of HPMC used (HPMC K100) gave the highest release rates at constant HPMC: drug ratio. The other three grades (HPMC K4M, K15M and K100M) showed similar release rates despite the variation in their molecular size.
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