Formulation of Oral Mucoadhesive Tablets of Pioglitazone using Natural Gum from Seeds of Pithecellobium Dulce

Abstract


 The plant derived gums and mucilage’s comply with many requirements of pharmaceutical excipients as they are non-toxic, stable, easily available, associated with less regulatory issues as compared to their synthetic counterpart and inexpensive; also these can be easily modified to meet the specific need. The present study was undertaken to isolate mucilage from the seeds of Pithecellobium dulce (P. dulce). The mucilage isolated from P. dulce were used as a bioadhesive polymer in tablet formulation and evaluated for the parameters such as swelling, pH, and bioadhesive property like bioadhesive strength, and ex-vivo residence time. The oral mucoadhesive tablets were prepared using Pioglitazone as model drug and P. dulce seeds mucilage as mucoadhesive polymer. The prepared tablets were evaluated against existing mucoadhesive polymer such as Xanthan gum and Hydroxyl Propyl Methyl Cellulose K4M to explore its use as Pharmaceutical excipients. Swelling index of P. dulce was found to be 87.46 ± 0.11 % which was higher than Xanthan gum but lower than HPMC K4M having swelling index 73.28 ± 0.01 % and 98.88 ± 0.03 % respectively. The results showed that Bioadhesion strength of P. dulce was found to be 50.86 ± 0.03N which was higher than HPMC K4M but lower than Xanthan gum having Force of adhesion 32.81 ± 0.04N and 57.17 ± 0.01N respectively. The percentage cumulative drug release drug release of optimize batch F8 was found to be 101.71 %. So, it was concluded that the mucilage of P. dulce can be used as a pharmaceutical excipient in oral bioadhesive drug delivery systems.