Formulation of Neomycin Sulphate 0.35 %(w/v) & Hydrocortisone 0.5% Otic Drop

Abstract

Neomycin sulfate and hydrocortisone ear drops of veterinary pharmaceuticals used as an antibiotic and ant inflammatory to treat infections caused by bacterial infections in the middle ear of large and small field animals caused by gram positive and negative bacteria like, Staphylococcus aureus, Escherichia coli, Homophiles influenza, Klebsiella–Enterobacter species, Neisseria species, and Pseudomonas aeruginosa. The action of mechanism neomycin sulfate is inhibition of protein synthesis in bacteria cell which is lead to kill the bacteria and the action of hydrocortisone is ant inflammation in the infected area in animals. In order for this preparation to be researched and applied, several primary pharmaceutical preparations were prepared until the final and stable structure was reached. The amount of the active substance at room temperature was 100%. This activity is good and within the permissible limits According to the veterinary constitutions [90-110].This process involved several stages of collecting information in the materials involved in the formulation and from effective and added materials And then the preparation of the composition according to the international pharmaceutical specifications using the constitutions of the drug followed by the study of stability and resistance to the product temperature room and then send samples for field examination Department of Veterinary, was used in the treatment of cases of bacterial infections of the middle ear infections in cats use 3 or 4 drops in the affected ear three or four times for 3-5 days and results came very good according the clinical evaluation.