Abstract
Objective: The aim of this study was to develop a microemulsion based gel system considering transdermal delivery of Salbutamol with a purpose to increase the solubility and membrane drug deliverance.
 Methods: Oleic acid was favored for oil phase owing to the proficiency of solubility in this study. Despite surfactant and co-surfactant was determined by virtue of their solubilizing strength wherewith they developed MEs. Accomplishing Franz diffusion cells equipped with cellulose membrane for in vitro study. The Polymer carbopol 934 were used for based gel preparation to enhance the viscosity of microemulsion for transdermal utilization. The advanced micro emulsion-based gel, which was assessed for pH, centrifugation, spreadability conductivity, drug content, viscosity, SEM, XRD and stability studies.
 Results: The process of drug escape from microemulsion gel-based was noticed to pursue Korsmeyer-peppas model kinetics. The designed, microemulsion gel-based displayed acceptable stability layer than 3 mo. Drug release microemulsion within 24 h was observed 74%.
 Conclusion: The results illustrate that deliberated effort to establish microemulsion based gel (F3) was likely to produce sustained action of drug release (78.3%) and be permitted auspicious vehicle for transdermal distribution of Salbutamol.
Highlights
In the past, people used to place solid material under the skin and oral dosage form to treat different pathological conditions but with the passage of time technological accomplishments have reduced the hurdles which were faced by the oral drug delivery system such as a first-pass effect,side effects and non-compliance of patients
The formulations exhibited pH in between (5.5 and 6.5) compatible to pH examined in previous Studies of formulations of salbutamol sulphate microemulsion based gel topically with respect to normal human skin pH range (4.5 to 6.5) [8, 13]
Drug content of salbutamol sulphate was in span of 97.10–99.31% and microemulsion based gel has shown good existence of Uniformity
Summary
People used to place solid material under the skin and oral dosage form to treat different pathological conditions but with the passage of time technological accomplishments have reduced the hurdles which were faced by the oral drug delivery system such as a first-pass effect,side effects and non-compliance of patients. Oral delivery of Salbutamol is infrequent, as this drug holds bioavailability of 50% by absorbing from the gastrointestinal tract and metabolism by liver. When microemulsion is assimilated with gel, it gives rise to emulgel possessing the qualities of both dosage forms with good bioavailability [5]. The motives of this research work are to formulate microemulsion based gel of salbutamol sulphate and to study its in vitro ex-vivo characteristics
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
