Abstract
Formulation of Mefenamic Acid Loaded Ethosomal Gel by Hot and Cold Methods
Highlights
Transdermal drug delivery system can be used as an alternative delivery of drug into the systemic circulation
Five formulations were in optimum range. They were characterized and evaluated in order to determine the best formulation for the preparation of mefenamic acid loaded ethosomes by hot method
The present investigation is the formulation of mefenamic acid transdermal gel based on vesicular drug delivery approaches
Summary
Transdermal drug delivery system can be used as an alternative delivery of drug into the systemic circulation. It is a better alternative to achieve constant plasma levels for prolonged periods of time, which could be advantageous because of less frequent dosing regimens [1, 2]. These systems include the use of physical means, such as iontophoresis, sonophoresis, microneedles, etc., chemical means like penetration enhancers and biochemical means using liposomes, niosomes, transferosomes and ethosomes. They have been reported to enhance the permeability of drug through the stratum corneum. The high concentration of ethanol makes ethosomes unique, because ethanol causes the disturbance of skin lipid bilayer organization
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