Formulation of Lipoprotein Microencapsulated Beadlets by Ionic Complexes in Algae-Based Carbohydrates

Alexandru Vasile Rusu,Daniel Mierliţă,Monica Trif,Claudia Terezia Socol,Florin Leontin Criste

doi:10.3390/coatings10030302

Alexandru Vasile Rusu, Daniel Mierliţă + Show 3 more

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https://doi.org/10.3390/coatings10030302

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Abstract

The present study aims to produce sustained-release algae-based carbohydrate microbeadlets of lipoproteins rich-in carotenoids extracted from organic sea buckthorn fruits. β-carotene represented the major compound of the lipoproteins extracts. Emulsification and algae-based carbohydrates, such as sodium-alginate and kappa-carrageenan, provide an inert environment, allowing the embedded targeted bioactive compounds—lipoproteins rich in carotenoids in our case—to maintain greater biological activity and to have a better shelf life. Furthermore, the microbeadlets prepared from sodium-alginate–kappa-carrageenan (0.75%:0.75% w/v) crosslinked with calcium ions showing 90% encapsulation efficiency have been utilized in HPMC capsules using beadlets-in-a-capsule technology, to use as a delivery system for the finished product. The GI simulated tests performed under laboratory conditions suggested that the sodium-alginate–kappa–carrageenan combination could be useful for the formulation-controlled release of microbeadlets containing lipoproteins rich in carotenoids.

Highlights

IntroductionTo enhance the bioavailability of orally delivered bioactive compounds, different strategies have been investigated to assure a proper solubility and a good intestinal permeability [1,2,3,4,5]
To enhance the bioavailability of orally delivered bioactive compounds, different strategies have been investigated to assure a proper solubility and a good intestinal permeability [1,2,3,4,5].Algae-based carbohydrate-encapsulating structures are continuously developed to ensure that the selected bioactives reach the lower gastrointestinal (GI) tract and establish protective mechanisms to combat metabolic syndrome
The lipoproteins rich in carotenoids as bioactive ingredients were encased in microbeadlets obtained from carbohydrate algae-based ionic complexes

Summary

Introduction

To enhance the bioavailability of orally delivered bioactive compounds, different strategies have been investigated to assure a proper solubility and a good intestinal permeability [1,2,3,4,5]. Algae-based carbohydrate-encapsulating structures are continuously developed to ensure that the selected bioactives reach the lower gastrointestinal (GI) tract and establish protective mechanisms to combat metabolic syndrome. Alginate and carrageenan are additives used as texturing These are a gelling agent and a thickener, which gives the required texture. Their ability to form a gel in the presence of calcium ions is used to produce an accurate form of a fibrous texture [6,7]. It is believed that carotenoids act in a dose- and time-dependent manner [8,9]

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