Abstract
The present work is concerned with the study of cow ghee as penetration enhancer in ketoconazole ophthalmic ointment as an ointment base with respect to conventional ointment base. Ophthalmic ointment was prepared with 1% ketoconazole, 0.01 % w /v Benzalchonium chloride and butylated hyroxytoluene B.P (0.02% ) with co w ghee as a base as well as petrolatum base and investigated their usefulness in the ophthalmological field by evaluating pH, acid value, freeze thaw cycle , isotonicity , corneal toxicity and in vitro transcorneal permeation study using excised goat cornea. cow ghee is an effective penetration enhancer as an ointment base. The interaction study between ketoconazole and cow ghee were f ound to be negative. Evaluation parameters such as pH, acid value, freeze thaw cycle, isotonicity, were carried out. Overall r esults suggest that cow ghee is safe for use as a penetration enhancer in ophthalmic delivery system as an ointment base.
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