Abstract
Abstract Surface modified self-nanoemulsifying formulations (SNEFs) loaded with gentamicin were formulated using suitable blends of soybean oil, a mixture of Kolliphor® P188 and Kolliphor® EL as surfactants, and Transcutol® HP as co-surfactant, and administered orally to white albino rats for evaluation of anti-pneumococcal activity against Streptococcus pneumoniae. Droplet size and zeta potential measurements showed that SNEFs had mean droplet sizes in the range of 80.7±0.5–210.2±0.0, and were stable with mean zeta potential in the range of –25.2±3.0 to –42.5±1.3 mV. Preliminary screening against S. pneumoniae in vitro revealed that gentamicin-loaded SNEFs had better bacterial inhibition than the standard drug, and at a low minimum inhibitory concentration (MIC) of 2.5 mg/mL. Gentamicin delivered into cerebrospinal fluid of rats from orally administered SNEFs produced a prolonged and enhanced activity against S. pneumoniae at a dose of 7 mg/kg than the standard drug at the same dose. Hence, results from this study showed that the activity of gentamicin against S. pneumoniae was improved by formulation as surface modified SNEFs.
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