Abstract
Ferrous fumarate has poor flow properties which cause compression problems. When ferrous fumarate is manufactured in combination with folic acid, the same problem is encountered. Therefore, a wet-granulation method is used for tablet manufacturing, which is a time-consuming and energy-wasting process compared to a directcompression method. In the present work, ferrous fumarate and folic acid (combination) tablets have been prepared using an optimized direct-compression technique that decreases the total manufacturing time of a batch (approx. 1.5 million tablets) from 24-28 h to only 2-3 h. The direct-compression technique is a simple and cost-effective method of manufacturing ferrous fumarate and folic acid (combination) tablets. Several formulations were developed using different proportions of avicel PH102, talcum, magnesium stearate, sodium lauryl sulfate, sugar, primojel, lactose, PVPK-30 and aerosil. Ten formulations were found to fulfill the specified criteria.
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