Formulation of Diclofenac tablets for rapid pain relief

Abstract

ObjectiveTo develop fast dissolving tablets of diclofenac in order to get fast relief from pain. MethodsFast dissolving tablets of diclofenac potassium were prepared by direct compression method using Indion 214, Indion 234, Indion 244 and croscarmellose as superdisintegrants. Microcrystalline cellulose was used as diluents and mannitol, as sweetening agent. Tablets were evaluated for weight variation; weight variation of all the formulations was observed which were within the acceptable limit for uncoated tablets as per United States Pharmacopoeia. ResultsMechanical strength, the hardness of tablets was determined and was found to be in the range of 6.4 to 7.13 Kg/cm2. In vitro disintegration time, the formulation containing indion214, indion234 andindion244 showed 34,31and 39 seconds value for in vitro disintegration respectively. Wetting time for all the formulations was found to be (4.425±0.25) to (5.75±2.25) seconds and the cumulative percentage drug release of formulations FD1- FD5. It was observed that in first 10 minutes, only 12.89% of drug was release from formulation FD5 without using superdisintegrants and while it was 88.56% in the case of formulation FD2. At the end of 24 minutes only 85.42 % of drug was released from the control tablet formulation FD5 whereas the cumulative release from other formulations FD1 and FD4 at the end of 12 minutes was 89.52 %and 79.29%, respectively. The results of in vitro disintegration time show that formulation containing Indion 244, showed the disintegration time of 29.66 seconds. ConclusionsIndion 244 was found to have super disintegrant property the addition technique is a best method for preparing fast dissolving tablets for rapid pain mangment.