Abstract
The correlation between the high content of selenium (Se) in plasma and the low prevalence of cardiovascular disease has been published in previous epidemiological studies. The content of Se in the plasma is determined by daily intake. A preliminary surveillance of Se content of several plants showed that the seeds of jengkol (Pithecellobium lobatum Benth.) has the highest concentration of Se. This study aims to develop a pharmaceutical formulation of Se supplement for adjuvant therapy of cardiovascular disease. The jengkol seeds was made into film coated tablets with a wet granulation method. Optimization of the core tablet formula was carried out with variations of binder concentration and coating material. Evaluation was carried out on uniformity of size and weight, disintegration time, hardness and friability. The content evaluation was carried out including the levels of Se, water content, ash, fat, protein, carbohydrate and crude fiber. The results showed that the F3 had the lowest friability and highest hardness. The coating of tablets using PVA has covered the smell of jengkol seed. The evaluation results showed that film coated tablets contained the Se level content of 0.074 ± 0.004 µg/g, water content of 2.19%, ash content of 1.88%, fat content of 0.89%, protein content of 0.66%, carbohydrate content of 94.38% and crude fiber content 1.79%. The results showed that the jengkol seed film coated tablet formulation could be used as a supplement in additional therapy for cardiovascular disease.Keywords : Pithecellobium lobatum, film coated tablet, herbal supplement, selenium
Highlights
The jengkol plant is a typical plant that grows in Southeast Asia, including in Indonesia
The jengkol fruit seeds tested came from 15 different regions in West Java
Measurement of Se content in jengkol fruit seeds was carried out using the Watkinson method
Summary
The jengkol plant is a typical plant that grows in Southeast Asia, including in Indonesia. This plant includes plants that are commonly eaten (edible plant). The used and consumed part of this plant is the seeds. Jengkol fruit seeds are commonly consumed by Indonesians, including those in West Java. The nutritional content contained in jengkol fruit seeds includes vitamin C, jencolic acid, tannins, flavonoids and saponins (1). Jengkol fruit seeds have a distinctive and pungent odor due to the presence of the amino acid cysteine which contains sulfur (2). Some plants contain Selenium (Se), one of which is the jengkol plant. It is necessary to first determine the Se content in the seeds of jengkol fruit to determine the range of Se content in the seeds of jengkol fruit because so far there has been no research that has conducted the determination of the Se content in the seeds of the jengkol fruit
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