Abstract
A wound indicates a discontinuity in the epithelial integrity of the skin along with structural and functional disruption of the underlying normal tissue. The study focused on chitosan stabilized silver nanoparticles (CH–AgNP) further incorporated in a chitosan-based (CH–AgNP–CHF) film for wound healing. Dual advantages of chitosan as a wound-healing agent in addition to the antimicrobial property of CH–AgNP nanoparticles was explored. Based on preliminary trials, 1–2% w/v chitosan as film former, 15–25% w/v glycerin as plasticizer and Teflon as casting surface was selected. The optimized CH–AgNP–CHF had tensile strength 1.39 ± 0.009 N/mm2, % Elongation 33.33 ± 1.634, 76.66 ± 0.584% degree of swelling, WVTR of 2024.43 ± 32.78 gm.m−2 day−1 and 1144.57 ± 13.45 gm.m−2 day−1 after 24 h and after 21 days respectively. The CH–AgNP–CHF reported highest % inhibition of 62.22 ± 0.91 against Escherichia coli as compared to chitosan solution, chitosan film and CH–AgNP solution. Based on in vivo animal study, CH–AgNP–CHF showed highest wound closure rate at 3rd, 5th, 7th, 14th and 21st day to indicate better and faster wound healing compared to marketed SilverKind® Nanofine gel, blank chitosan film and sterile gauze treated group (Control). Thus, CH–AgNP–CHF is more effective alternative for wound healing.
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