Year-end Sale % OFF 
Abstract
Purpose: This study was designed to develop and evaluate chitosan films containing ciprofloxacin and diclofenac sodium for the topical treatment of periodontitis. Methods: Chitosan films containing ciprofloxacin alone and in combination with diclofenac sodium were prepared by solvent casting method. Some of the drug-loaded films were crosslinked with 2% gluteraldehyde for 2 and 4 h, respectively. The films were then evaluated for their physicochemical properties including weight variation, thickness, tensile strength, in vitro release, stability and antibacterial activity. Results: Mean weight and thickness data showed that the different films were uniform. Tensile strength was maximum for drug-free films and minimum for films containing the highest amount of drug(s). In vitro drug release data indicate that the films showed an initial burst release followed by sustained release of the drug(s). Films stored at refrigerated conditions exhibited slower degradation rate. The drug-loaded films that were crosslinked for 4 h had inhibitory effect on Staph mutans for up to 24 days. Conclusion: The study suggests that crosslinked chitosan film containing ciprofloxacin and diclofenac is a potential drug delivery device for the topical treatment of periodontitis. Good physicochemical properties were shown by the films. Keywords: kChitosan, Ciprofloxacin, Crosslinking, Diclofenac, Films, Topical delivery, PeriodontitisTropical Journal of Pharmaceutical Research Vol. 8 (1) 2009: pp. 33-41
Highlights
Periodontal diseases are infections affecting a significant proportion of people in all populations[1]
Some patients may experience continued periodontal attachment loss[4], and this may be due to some periodontal pathogens that are inaccessible during mechanical periodontal therapy
Tensile strength was lowest for uncrosslinked films and highest for crosslinked films and was in the range, 0.541 - 1.87 kg/mm[2]
Summary
Periodontal diseases are infections affecting a significant proportion of people in all populations[1]. The presence of periodontal pathogens such as Porphyromonas gingivalis, Prevotella intermedia and Actinobacillus actinomycetemcomitans are responsible for periodontal destruction[2]. An objective of periodontal treatment is to suppress or eliminate subgingival periodontal pathogens. This is generally achieved through subgingival debridement, resulting in the reduction of the total bacterial load[3]. Some patients may experience continued periodontal attachment loss[4], and this may be due to some periodontal pathogens that are inaccessible during mechanical periodontal therapy. It is conceivable that local and/or systemic administration of effective antimicrobial agents may enhance the outcome of mechanical therapy[5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
