Formulation of chewable lozenges of Som Jawa (Talinum paniculatum (jacq.) gaertn) leaves extract applied as antiscorbut Candida albicans

Abstract

Background: The bioactive compounds of Som Jawa (Talinum paniculatum (Jacq.) Gaertn) have many variations;one of them is flavonoid. This compound has antifungal activity towards Candida albicans, which the leading cause of topical infection. Chewable lozenges are one of the novel methods of delivering drugs for local action, especially in the mouth. Objective: To formulate chewable lozenges from Som Jawa leaves extract and evaluate their active substances. Methods: Extraction was done by rmaceration method with ethanol. The extract was evaporated using a rotary evaporator, then followed by a phytochemical investigation to express the active ingredients inside extract. Colour test was used to identify active ingredients. Som Jawa leaves extract was then formulated into chewable lozenges. Testing of physical properties of the chewable lozenges includes organoleptic test, weigh uniformity, hardness, elasticity, friability, chewiness and moisture content. Antifungal activity was tested by using a diffusion method. Result : Som Jawa leaves extract with the concentration of 50% can inhibit the growth of Candida albicans with inhibition zone diameter of 22.69 mm. The organoleptic test resulted that the dosage is odourless, brown, and chewy. Weigh uniformity resulted that all lozenges were meet the British Pharmacopoeia range with the CV < 5%. The hardness test resulted for approximately of 0.2732 Kgf. The average of elasticity, friability, and chewiness respectively was 0.0826 Kgf, 6.046 mm, and 0.4998 Kgf.mm. Conclusion: This formula chewable lozenge was potential as alternative herbal medicine for topical infection.