Abstract
Flavonoid is a polyphenolic antioxidant used to treat free radical mediated tissue damage. So flavonoids are the good targets for treatment of many diseases like cancer, toxicity health hazards, neurodegenaration etc. Drug delivery of flavonoid is the novel approach where dosing and drug toxicity can be minimized. Antioxidant Catechin Hydrate (CH) is choosen to make drug delivery vehicle: nanocapsules either alone or in combination with chelator sodium meta borate (SMB) within biodegradable poly-lactide-co-glycolide (PLGA). Sizes of the prepared particles were determined through scanning and atomic force microscopy where less than 50 nm particle sizes were revealed. Bioavailability in serum study determines that shelf life of CH can be increased with nanocapsule delivery compared to free drug. Results demonstrate the efficacy of Nanocapsulated CH to be a potent vehicle for tissue targeting.
Highlights
Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect
Further it demonstrates the role of oral application of chelator sodium meta borate and antioxidant catechin hydrate in a nanocapsulated form to prevent the toxic effect of fluoride in response to chronic fluoride exposure
poly lactic-co-glycolic acid (PLGA) nanoparticles were prepared and used to encapsulate, protect and release the bioactive flavonoid molecule catechin hydrate. We showed that this flavonoid was successfully encapsulated in a non crystalline state within the PLGA nanocapsule matrix using the didodecyldimethylammonium bromide (DMAB) as a stabilizer
Summary
Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. It may involve scientific site targeting within the body, and facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of drug’s persistence in the system. The choice of the delivery systems is to allow the safe application of the drug with minimum losses. This suggests that the drug in the formulation must be chemically, physically and microbiologically stable. Side-effects of the drug and drug interactions should be avoided or minimized by the use of suitable drug delivery systems
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