Abstract
BackgroundCurrently, people are more interested to traditional medicine. The traditional formulations should be converted to modern drug delivery systems to be more acceptable for the patients. In the present investigation, a poly herbal medicine “Ayarij-e-Faiqra” (AF) based on Iranian traditional medicine (ITM) has been formulated and its quality control parameters have been developed.MethodsThe main ingredients of AF including barks of Cinnamomum zeylanicum Blume and Cinnamomum cassia J. Presl, the rhizomes of Nardostachys jatamansi DC., the fruits of Piper cubeba L.f., the flowers of Rosa damascena Herrm., the oleo gum resin of Pistacia terebinthus L. and Aloe spp. dried juice were powdered and used for preparing seven tablet formulations of the herbal mixture. Flowability of the different formulated powders was examined and the best formulations were selected (F6&F7). The tablets were prepared from the selected formulations compared according to the physical characteristics and finally, F7 was selected and coated. Physicochemical characters of core and coated AF tablets were determined and the HPLC method for quantitation of aloin as a marker of tablets was selected and verified according to selectivity, linearity, precision, recovery, LOD and LOQ.ResultsThe results showed that core and coated AF tablets were in agreement with USP requirements for herbal drugs. They had acceptable appearance, disintegration time, friability, hardness, dissolution behavior, weight variation and content uniformity. The amount of aloin in tablets was found 123.1 mg/tab. The HPLC method for aloin determination in AF tablets was verified according to selectivity, linearity (5–500 μg/ml, r2:0.9999), precision (RSD: 1.62%), recovery (108.0%), LOD & LOQ (0.0053 & 0.0161 μg/ml).ConclusionsThe formulated tablets could be a good substitute for powder and capsules of AF in ITM clinics with a feasible and precise method for its quality control.Graphical abstractAyarij-e-Faiqra formulation
Highlights
People are more interested to traditional medicine
They were identified by the botanists of the Traditional Medicine and Materia Medica Research Center (TMRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran and their voucher specimens were deposited at TMRC Herbarium for further reference (No 342, 341, 343, 345, 346, 348 and 347 HMS, for the barks of C. zeylanicum and C. cassia, the rhizome of N. jatamansi, the fruit of P. cubeba, the flower of R. damascena, the oleo gum resin of P. terebinthus and dried juice of Aloe spp., respectively)
The amount of dissolved aloin was determined by High Performance Liquid Chromatography (HPLC) using 5 ml filtered portions of the samples and aloin standard solution (0.1 mg/ml) in methanol: water (1:1). (Q) more than 75% was considered as acceptable for dissolution test
Summary
People are more interested to traditional medicine. The traditional formulations should be converted to modern drug delivery systems to be more acceptable for the patients. A poly herbal medicine “Ayarij-e-Faiqra” (AF) based on Iranian traditional medicine (ITM) has been formulated and its quality control parameters have been developed. The World Health Organization (WHO) has admitted the influence of traditional and complementary medicine in the well-being of people and has developed instructions for supporting the Iranian traditional medicine (ITM), its summit by Avicenna in tenth century, is one of the oldest and richest holistic medical systems that has promote healthy life [1]. ITM believes that balance in the four humors (phlegm, blood, yellow bile and black bile) establishes a healthy body and imbalance would result in illness. A healthy human body expels the waste humors through urine, feces, perspiration, sputum, menses (in women) and some other body’s secretions. ITM believes in regulation or elimination of the waste humor to
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