Abstract
Objective: Fast-disintegrating tablets are a pharmaceutical preparation that is rapidly being developed because they can dissolve in the oral cavitywithout chewing and without additional water support. The type of dissolver is a crucial component in fast-disintegrating tablets. Maltodextrin andpregelatinized cassava starch (PPS) are excipients that can be used as dissolvers. This study aimed to formulate fast-disintegrating tablets using acombination of maltodextrin dextrose equivalent (DE) 10-15 and PPS in various concentrations as excipients.Methods: The cassava starch classified as PPS was obtained. PPS was then mixed with maltodextrin DE 10-15 to create fast-disintegrating tabletsusing the wet granulation method.Results: Tablet evaluation showed that formula F containing 40% maltodextrin DE 10-15 and 10% PPS was the most effective of the proposed fastdisintegratingtablets.Conclusions: Formula F has a hardness of 3.39 kp, 0.74% friability, a wetting time of 7.87 seconds, and a dissolve time of 38.55 seconds.
Highlights
Today, many types of pharmaceuticals are being developed
Tablet evaluation showed that formula F containing 40% maltodextrin dextrose equivalent (DE) 10-15 and 10% PPS was the most effective of the proposed fastdisintegrating tablets
Maltodextrin is the product of partial starch hydrolysis containing a α-D-glucose unit attached to (1 → 4) glycoside with a dextrose equivalent (DE) value
Summary
Fastdissolving tablets are an example of this development This type of tablet is designed to instantly dissolve in the oral cavity when it comes in contact with saliva after it is placed on the tongue without chewing or without the help of water to release the drug [1,2]. Previous research has shown that PPS can be used as a single dissolver in fast-disintegrating tablets because of its ability to expand when it comes in contact with water [8]. Maltodextrin DE 10-15 was combined with PPS as excipients in the fast-disintegrating tablet to determine their effectiveness as dissolvers. The resulting tablets were evaluated based on the requirements found in Pharmacopeia III and Pharmacopeia IV, and other literature, to determine the time it takes for each tablet to dissolve
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