Abstract
The search for new cytotoxic agents results in many active compounds being discovered. The analysis, pharmacokinetic studies and formulation of these new drugs may be complicated by their physicochemical properties. One such drug intended for parenteral administration was α-TGT and in this study physicochcmical characteristics of TGT have been investigated. The aqueous solubility of TGT was doubled or trebled by the addition of non-ionic surfactants. The drug was found to degrade upon exposure to ρ-irradiation and heat, rendering these methods unsuitable for sterilizing the drug. TGT solution has to be sterilized by filtration and the sterile product freeze-dried if the product is to be stored for a long time before being used. Of the intravenous infusion fluids studied, only dextrose 5% solution was found to be suitable as a vehicle for TGT.
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