Abstract
BackgroundA simvastatin nanostructured lipid carrier loaded transdermal patch was developed to enhance the bioavailability and therapeutic effect.MethodsSimvastatin NLC preparation was prepared by optimized hot homogenization technique and were characterized by particle size in nanometer, polydispersity index, zeta potential in millivolt, scanning electron microscopy, and entrapment efficiency by applying Box Behnken design utilizing multiple linear regression method.ResultsChosen optimized NLC F7 formulation has particle size of 125.4 ± 2.66 nm, zeta potential of − 33.6 ± 2.42 mV, and PI of 0.480 ± 0.24. The NLC was loaded in transdermal patch by solvent evaporation method and evaluated for physical characteristics, drug content, skin permeation studies, and in-vivo pharmacokinetic studies in male albino Wistar rat. In-vivo pharmacokinetic studies in NLC loaded transdermal patch show an increase in AUC0-α in mg/ml when compared to marketed oral dosage form, which confirms the enhancement of bioavailability of simvastatin by NLC loaded transdermal patch.ConclusionsFrom the data, it was concluded that drug-loaded NLC transdermal patch will be a promising drug delivery system for poorly bioavailable drugs.
Highlights
A simvastatin nanostructured lipid carrier loaded transdermal patch was developed to enhance the bioavailability and therapeutic effect
From which we can conclude that preferred functional group frequencies are reproducible in nanoparticleNanostructured lipid carriers (NLCs) and transdermal patch when compared to the standard drug
Reproducible main functional groups wave numbers like –OH stretching as 3551.55 cm−1, 2966.58 cm−1, 2872.80 cm−1, -C=O stretching as 1723.73 cm−1, -C-O stretching as 1118.85 cm−1, -C-H bending as 990.20 cm−1 in pure drug; –OH stretching as 3340 cm−1, 2944.50 cm−1, 2832.87 cm−1, -C-O stretching 1251.09 cm−1, 1081.79 cm−1 in NLC; –OH stretching as 3648.38 cm−1, 2922.12 cm−1, 2853.69 cm−1, -C=O stretching as 1732.87 cm−1, -C-H bending as 930.75 cm−1 in transdermal patch respectively
Summary
Simvastatin NLC preparation was prepared by optimized hot homogenization technique and were characterized by particle size in nanometer, polydispersity index, zeta potential in millivolt, scanning electron microscopy, and entrapment efficiency by applying Box Behnken design utilizing multiple linear regression method
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