Abstract
In this study, novel nonionic microemulsions (MEs) stabilized using a mixture of Span 20 and Tween 80 were developed for the transdermal delivery of ferrous sulfate. The MEs were evaluated in terms of their droplet size and zeta potential as well as their rheological properties using bob and cup rheometer. In addition, the flux of ferrous sulfate loaded in the MEs through shaved rat's skin was studied using Franz diffusion cells. The in vivo efficacy of developed MEs was evaluated in anemic rats over two weeks. The droplet sizes of the developed MEs were less than 180 nm and decreased with increasing ferrous sulfate content. The microemulsions showed a Newtonian flow behavior. Ferrous sulfate's flux was proportional to its concentration in the ME with a maximum flux achieved being 13.03 μg/cm2. hr. Furthermore, anemic rats treated with ferrous sulfate - loaded ME recovered faster than the control group.
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