Abstract
The aim of current research was to formulate the pulse-release tablets of Atenolol and investigate its in-vitro performance so the study was designed to firstly increase the solubility and bioavailability of drug by formulating the fast dissolving core tablet of cyclodextrin drug- complex, using spray dried lactose, spray dried mucilage -lactose & superdisintegrants by direct compression method. Then Pulsatile tablets were prepared by compression coating using 2 3 factorial design using different polymers as independent variables in which lubritab, xanthan gum, Polyox WSR301 and dicalcium phosphate,were used for maintaining lag time in different concentrations and controlling the drug release by direct compression and dependent variable as lag time. The formulations were investigated for lag time by in-vitro dissolution study. Formulation was optimized on basis of acceptable tablet properties and in vitro drug release. Formulation F7 was selected on basis of factorial design dependent variable i.e., the lag time.
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