Formulation evaluation and stability studies of hydrogel tablets containing Cefditoren Pivoxil

Abstract

AimCefditoren Pivoxil hydrogel tablets were prepared to achieve the gastro retentive effect in order to improve its absorption and bioavailability. MethodsThe formulations were made by varying the concentrations of carbopol and sodium alginate. The prepared blends were compressed directly using a 16-station rotary punch tablet machine (Cadmach, Germany) having caplet shaped concave punches. Stability studies for the selected formulation were performed as per the ICH protocol. ResultsThe pre-compression parameters and post compression parameters were within acceptable pharmacopeial limits. The tablets prepared with sodium carbonate showed good porosity in the swelling index studies. The in-vitro dissolution behavior shows that the formulations that contain carbopol (100 mg) and sodium alginate (30 mg) were found to have good controlled release of 95.012% at 24th hour. ConclusionBy preparing Cefditoren Pivoxil hydrogels with the above mentioned polymers gastro retentive effect was achieved, further the drug release can be controlled.