Abstract
The purpose of this research work was to formulate & evaluate the herbal fast dissolving tablet of Nyctanthes Arbor Tristis. Taxonomically, the plant was authenticated by the Padmashri vikhe patil college of Arts, Science, & Commerce in pravaranagar. Ref.No./PVPC/Bot./2023-24/235. The aimed is to treat inflammation associated with Sciatica. A two independent variables of superdisintegrants are used such as crosspovidone & croscarmellose sodium. Using DOE software, 32 full factorial design was used to examine the combined impact of two formulation variables. TLC was performed to identify the beta sitosterol with RF value of 0.77. to determine the physicochemical interaction between the drug & the excipients, FTIR study was done. FTIR study revealed that there is no interaction of the drug and excipient. In this investigation, the tablets were formulated and assessed via direct compression. The powder mixture were compressed into tablet using single punch tablet machine. All the formulations were evaluated for their characteristic such as weight variation, hardness, thickness, friability, disintegration time(DT), and dissolution rate. It was determined from all evaluation parameter that the F9 batch was the optimized batch. It was found that an optimized batch (F9) has good cumulative drug release in 20 minutes (88.87%), DT of 56 seconds, and hardness of 2.923kg/cm2. The comparative studies are done with the marketed formulation. With the commercial formulation, the optimized batchF9 satisfies all standard specification.
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