FORMULATION DOSAGE FORM OF TABLET CONTAINING KEPEL LEAF EXTRACT (Stelechocarpus burahol (Blume) Hook.f &amp; Thomson) AS AN ANTIMICROBIAL AGENTS

Hilda Maysarah,Meutia Faradilla,Tedy Kurniawan Bakri,Misrahanum Misrahanum

doi:10.24815/jn.v19i2.12151

Abstract

Pharmaceutical dosage form that contains herbal materials has been developed in order to make it easy to consume. Tablet is one of pharmaceutical dosage form that generally used. A formulation and antimicrobial test of tablet containing extract of Kepel leaf with different concentration of diluents, binders, and disintegrants has been studied. The evaluation test showed that formulation consist of 25 % of Kepel leaf extract, 64.5 % of avicel PH 102, 2 % of PVP, 7 % of amprotab, 0.5 % of aerosil, and 1 % of talcum are better than the others. The experimental method used in this study was wet granulation. From the result of the mass granulation evaluation, it was obtain that speed flow without vibration was 2.53 second, with vibration was 2.83 second, bulk density was 0.329 g/mL, taped density was 0.376 g/mL and compressibility was 12.65 %. The result of tablet evaluation obtained that the average weight was 498 mg, with the average hardness was 4 kg/cm2 and disintegration time was 2.36 minutes. Antimicrobial test showed that in the concentration of 50 mg/mL, had average inhibitory diameter against S. aureus of 12.96 mm, P. aeruginosa 12.7 mm, and against B. subtilis was 12.53 mm. Whereas, concentration of 62.5 mg/mL had average inhibitory diameter against S. aureus was 13.5 mm, P. aeruginosa was 13.56 mm, and against B. subtilis was 13.43 mm. Both concentrations did not have antimicrobial activity against E.coli.

Highlights

Tablets are the most popular dosage form because they are easy to use, relatively low production costs, relatively precise dosages, and physically more durable in storage, chemically and physically stable
Increased levels of Avicel PH 102 are expected to increase the compressibility of the tablet so that the tablet is not brittle
Granule Mass Evaluation Granule testing needs to be done to determine the feasibility of the granule mass to further be able to do the tableting process

Summary

INTRODUCTION

Tablets are the most popular dosage form because they are easy to use, relatively low production costs, relatively precise dosages, and physically more durable in storage, chemically and physically stable. Herbal or natural ingredients can be made in pharmaceutical dosage forms with nutritious ingredients derived from plant extracts, a tablet dosage form for example. Kepel or burahol leaves can be used to prevent body odor, especially those caused by microorganisms. The research showed the extracts and fractions of the kepel leaves which inhibited the growth of microbes that cause body odor include Staphylococcus aureus, Staphylococcus epidermidis and Candida albicans [2]. Methanol extract from Kepel leaves gave inhibitory to Staphylococcus aureus with the Minimum Inhibitory Concentration (MIC) obtained at a concentration of 25% b/v with a inhibitory diameter of 14. Methanol extract from Kepel leaves gave inhibitory to Staphylococcus aureus with the Minimum Inhibitory Concentration (MIC) obtained at a concentration of 25% b/v with a inhibitory diameter of 14. 465 mm

METHODOLOGY

RESULTS AND DISCUSSION

Result

CONCLUSION