Abstract
Because of the increasing prevalence and changing microbiological spectrum of invasive fungal infections, some form of amphotericin B still provides the most reliable and broad spectrum therapeutic alternative. The research aimed to formulate and prepare chitosan nanaoparticle incorporated gel of low molecular weight chitosan nanoparticles with the help of antifungal agents amphotericin B for the topical application. Using the ionic gelation process, nanoparticles containing drugs were prepared. By cationic interaction is suitable for pH, and gel sodium tripolyphosphate is used as a crosslinker which cross-links the chitosan particles to form the gel, interaction between drug and polymer was observed during the formulation development. The gel was prepared and evaluated for viscosity, % assay, extrudability, spreadability and drug release study. It was found that viscosity of prepared gel was 4520cps, % assay was 98.96±0.35, Extrudability was 167g and Spreadibility (g.cm/sec) was found that 11.95 (g.cm/sec) respectively table 3. In vitro drug release from chitosan nanoparticles gel was carried out using Franz diffusion cell method and found 92.23% in 12 hr.
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