Abstract
Objective: Aim of the study was to formulate, evaluate and optimize medicated Lip rouge containing acyclovir encapsulated inside a novel vesicular carrier, niosome so that the formulation can improve its membrane penetration. Formulating as a cosmetic Lip rouge formulation will also improve patient compliance in the treatment of herpes labialis.Methods: Acyclovir niosomes were prepared by thin film hydration method. Niosomes were evaluated and were optimized by considering the entrapment efficiency and in vitro release profile. The optimized niosomes were incorporated into lipstick, lip balm and lip rouge for selecting the best lip formulation. Based on the in vitro release profile, ease of application and properties of prepared formulations lip rouge was selected and further evaluations were carried out.Results: Among the six formulations of niosomes NF2 has showed 88.49 % entrapment efficiency and 86.97% cumulative drug release in 8 h. The formulation was optimized considering both entrapment efficiency and in vitro release. The optimized formulation of niosomes was incorporated into Lipstick, lip balm and lip rouge. The evaluation results of lipstick, lip balm and lip rouge for in vitro release suggested lip rouge as the best formulation. The percentage cumulative release of drug from optimized lip rouge at the end of 8 h was 84.77%. The percentage cumulative drug release in ex vivo studies for 8 h was 60.88 %.Conclusion: The results suggested that prepared lip rouge containing acyclovir niosomes can effectively deliver the drug than the marketed acyclovir cream and successful therapy of Recurrent Herpes labialis can be achieved.
Highlights
IntroductionHerpes labialis (cold sores) is a condition which affects the skin and mucous membranes (the lips) that are preceded and accompanied by burning pain
Herpes labialis is a condition which affects the skin and mucous membranes that are preceded and accompanied by burning pain
Acyclovir 5% cream is used for the treatment of herpes labialis along with oral dosage forms like tablets
Summary
Herpes labialis (cold sores) is a condition which affects the skin and mucous membranes (the lips) that are preceded and accompanied by burning pain. Acyclovir is the common antiviral agent that is used for the treatment of Herpes labialis. Acyclovir 5% cream is used for the treatment of herpes labialis along with oral dosage forms like tablets. These formulations show poor therapeutic outcome due to the poor bioavailability (15-20%) of oral dosage forms and poor penetration of the drug from topical formulations across the lip membrane. Acyclovir is a BCS class III Drug having limited permeability. Enhancement of penetration of Acyclovir through the lip membrane will increase the therapeutic outcome [1]
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