Abstract

Objective: Preparation of Rosuvastatin Calcium by Using Hydrophilic Polymers and Solid Dispersion Method, Rosuvastatin calcium is a Dyslipidaemic agent, which act as a selective competitive inhibitor of HMG CoA educates enzyme and is used in the treatment of hyperlipidemia.
 Methods: In the present work, Solid Dispersion was prepared by kneading method to increase the solubility of Rosuvastatin Calcium.
 Results: Solid dispersions were evaluated by determining percentage yield, drug content, solubility, Scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), DSC and in vitro dissolution profile. The prepared solid dispersion are formulated into capsule dosage form and characterized by various parameters i.e. weight variation, content uniformity, disintegration and dissolution. The evaluated parameters of capsule dosage form increase in solubility and dissolution rate of the pure drug.
 Conclusion: These are various techniques to enhance the solubility of the drug, such as particle size reduction, use of surfactants, solid dispersion etc. Carriers are the major players in these formulations, e. g. Hydroxypropylmethylcellulose, ethylcellulose, Carbopol, Acacia Gum etc. Carbopol and Acacia Gum is one of the most efficient polymers work as a carrier for these drugs to enhance solubility.

Highlights

  • The solubility and dissolution rate of medication determine its oral bioavailability, and dissolution rate may be a rate-determining step for the emergence of medicinal action

  • The melting point of rosuvastatin calcium was found to be in the range of 173-185 °C by Capillary method

  • Absorption maxima (λ max) of rosuvastatin calcium were observed in different solvents

Read more

Summary

Introduction

The solubility and dissolution rate of medication determine its oral bioavailability, and dissolution rate may be a rate-determining step for the emergence of medicinal action. Regardless of the chemical structure or molecular space dimension, certain methods may be employed to enhance the solubility of medicines. Solid dispersion has become one of the most active areas of study in the pharmaceutical industry because it improves medication solubility [1, 2]. Solid dispersion is a suitable technique in which one or more active substances are dispersed in a solid form in an inner carrier or matrix produced by melting, dissolving in the solvent, or melting solvent method. Dissolution is defined as the process by which a solid material is solubilized in a given solvent, i.e., mass transfer from the solid surface to the liquid phase, while solubility is defined as the greatest quantity of solute that can be dissolved in a given amount of solvent [3,4,5]

Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call