Abstract
Injuries are lost or damaged part of the body's tissues. Wounds are also defined as physical damage due to the opening or destruction of the skin which can cause abnormal skin function and anatomy. These plants widely used traditionally from fresh noni leaves used as a medicine for broken bones, cuts, burns and pain by boiling and drinking the juice. These studys to make use of more effective and efficient Noni leaf extract made in cream preparations as a wound medicine, so that people are easy to use. This study used an experimental research method, namely the cream formulation of noni concentrated ethanol extract of 5%, 10% and 15%. Cream preparation evaluation test included: Organoleptic, pH test, cream type test, homogeneity test, sticky power test, dispersion test and protection power test. The test method was carried out on mice by means of cream preparations applied to the back of mice which were given an incision wound. Its effectiveness is seen from the measurement of wound length for seven days to calculate the percentage of wound healing power. The results of the One Way ANOVA test showed that there were significant differences between concentrations of 5%, 10% and 15% with significant values <0.05. The percentage of healing power of noni leaf extract cream concentration of 5% = 7,69%, concentration of 10% = 17,26%, and concentration of 15% = 29,35%. The results showed that the ethanol extract of noni leaves can be made in cream dosage form and has the effectiveness to accelerate the healing of incision wounds in mice.
Highlights
Intoduction For a long time humans used plants and natural ingredients as a medicine to reduce pain, heal, and prevent certain diseases, beautify themselves and maintain the condition of the body to stay healthy and fit
One of the medicinal plants that is often used by people is mengkudu (Morinda citrifolia L) which is internationally known as "noni" which is a typical term of Hawaiian people
Simplicia which is used for making cream of ethanol extract of noni leaf extracted in the Sukoharjo area, noni leaf which is used as a sample of leaves that are still fresh and have criteria, namely the leaves have a length of 10 cm - 30 cm, width 5 cm - 17 cm, green as much as 300 grams While the test animals used were male mice that had no anatomical defect criteria, had an age of approximately 5 weeks and weighed 20-30 g. 25 test animals were used
Summary
Intoduction For a long time humans used plants and natural ingredients as a medicine to reduce pain, heal, and prevent certain diseases, beautify themselves and maintain the condition of the body to stay healthy and fit. Information : Ptn-1 : The average length of wound healing intn – 1 Ptn : Length of average wound healing at tn Formulation Development And Physical Test Of Leaf Ethanol Extract Cream Noni (Morinda Citrifolia L)As A Wound Healer
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