Abstract
Abstract: Objectives: The intention of present study is to formulate and optimize the famotidine mucoadhesive tablets y using Central Composite Design. Materials and Methods: The concentrations of Cordia dichotoma fruit mucilage powder (X1) and Polyvinyl pyrrolidone (X2) were demonstrated as independent variables. Whereas, the dependent variables were selected such as an in vitro Mucoadhesion Time and percentage Drug Release. The model was considered to be nonlinear and the curvature effect was significant. Hence, the study reported to Central Composite Design. By using wet granulation method, the tablets were prepared and all the formulated tablets were evaluated for its post compression parameters. Results: The drug and the excipients had no interaction, according to FT-IR and DSC analyses. All formulations showed Mucoadhesion Time ranging from 5 hr to 9 hr and % Drug Release in the range of 96.4% to 99.69%. The association amongst the dependent variable and independent variables was judge by using Contour plots. Conclusion: The outcomes indicated the efficacy of the proposed design for famotidine Mucoadhesive tablets development. Keywords: Optimization, Central Composite Design, Drug Release, Famotidine, Muco adhesive.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Indian Journal of Pharmaceutical Education and Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
