Formulation development and in vitro evaluation of provesicular gel of ketoprofen for management of Arthritis

Abstract

The fundamental principles and uses of transdermal drug delivery, which is a method for therapeutic drug delivery through the skin as an alternative to oral, intravascular, subcutaneous, and transmucosal routes. Arthritis is a chronic condition that affects nearly a quarter of the United States population. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two major forms of arthritis associated with severe joint pain and reduced quality of life. Various pharmacological interventions may be utilized for arthritis treatment when non-pharmacological therapy is insufficient. However, pharmacological therapy can be associated with serious side effects and high costs. Therefore, alternative therapies have been under investigation. Some (details in tables) medications have shown the potential for safe and effective management of arthritis. this review, we attempt to summarize the mechanisms, diagnosis, treatments, clinical significant for OA and RA and all type of arthritis. The present study aims to formulate and evaluate the effectiveness of vesicular gel of ketoprofen in induced animal model. In the present work, optimization formulations of vesicular gel were prepared. Lecithin was used as polymers. The vesicular gel containing drugs and excipients were subjected to various evaluation test such as Preformulation study of drug, Particle size distribution, Morphology, Photomicroscope, Transfusion, SEM,TEM, In vitro, and Kinetic release. Various kinetic models to evaluate correlation coefficient and release rate constant. It was found that for the formulation, value of correlation coefficientof Korsemmayer Peppas equation is nearer to 1.0 and hence it can be predicted that the release from prodeformable vesicles follow Korsemmayer Peppas kinetics.