Abstract
The aim of this work was to develop Alendronate mucoadhesive buccal tablets. Buccal tablets of Alendronate are designed to release drug at mucosal site for extended period of time without wash out of drug by saliva. Sodium alginate, Ethyl cellulose and Carbopol were selected as mucoadhesive polymers on the basis of their matrix forming properties. The objective of the study is to improve the bioavailability of Alendronate buccal tablets. In present study, an attempt was made to design mucoadhesive buccal tablets containing Alendronate, Sodium alginate, Ethyl cellulose and Carbopol using as polymers. The tablets were prepared by direct compression method. The formulations were evaluated for hardness, thickness, friability, weight variation, drug content estimation, surface pH determination, swelling index, in vitro drug release. The obtained results of various evaluation parameters are described in post compression studies. The results of in vitro release study were in full support of swelling study. In vitro release data of optimized formula F11 fitted into various release kinetic models to study the release mechanism. All the prepared tablets were stable at different temperature and shows good mucoadhesive properties.
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