FORMULATION DEVELOPMENT AND EVALUATION OF SITE SPECIFIC PERIODONTAL GELS

Abstract

Periodontal pockets act as a natural reservoir filled with gingival crevicular fluid for the controlled release of antimicrobials directly. This work reflects the present status of nonsurgical controlled local intrapocket delivery of antimicrobials in the treatment of periodontitis. These sites have specialty in terms of anatomy, permeability and their ability to retain a delivery system for a desired length of time. A number of antimicrobial products and the composition of the delivery systems, its use, clinical results, and their release are summarized. In the present study development of site specific periodontal drug delivery system was developed for Metronidazole and Minocycline HCl. Metronidazole is an important active substance that has been widely used in the treatment of some protozoal and anaerobic bacterial infections. Minocycline hydrochloride is a semi synthetic tetracycline, which has been primarily indicated for the treatment of Acne vulgaris. Polarizing photographs of gel lacking CMC, PVP and a gel encircling 10% CMC and 5% PVP are naked. Photographs demonstrated a dark background in the instance of plain gel, though some fan like formations were supposed in the polarizing photograph of the P5C10 formulation. The consequence of drug(s) concentration on gelation and gel melting is done. The gelation temperature was miserable in the company of drug(s) and conical linearly with its growing concentration, while the melting temperature amended with the concentration of drug(s). The mechanical properties of the augmented formulations for the supervision of periodontal disease were resolute.