Abstract
Hyperlipidemia is a crucial risk factor for the initiation and progression of atherosclerosis, ultimately leading to cardiovascular disease. The nanogel-based nanoplatform has emerged as an extremely promising drug delivery technology. Pravastatin Sodium (PS) is a cholesterol-lowering drug used to treat hyperlipidemia. This study aimed to fabricate Pravastatin-loaded nanogel for evaluation of its effect in hyperlipidemia treatment. Pravastatin-loaded chitosan nanoparticles (PS-CS-NPs) were prepared by the ionic gelation method; then, these prepared NPs were converted to nanogel by adding a specified amount of 5% poloxamer solution. Various parameters, including drug entrapment efficacy, in vitro drug release, and hemolytic activity of the developed and optimized formulation, were evaluated. The in vitro drug release of the nanogel formulation revealed the sustained release (59.63% in 24 h) of the drug. The drug excipients compatibility studies revealed no interaction between the drug and the screened excipients. Higher drug entrapment efficacy was observed. The hemolytic activity showed lesser toxicity in nanoformulation than the pure drug solution. These findings support the prospective use of orally administered pravastatin-loaded nanogel as an effective and safe nano delivery system in hyperlipidemia treatment.
Highlights
The term ‘nanogel’ is defined as the nanosized particles formed by a cross-linked polymer physically or chemically
The 32 level central composite design (CCD) with results is shown in Tables 1 and 2
This study found that chitosan and poloxamer gave a desired particle size for all the batches, which was found to be 400–3155 nm with a lower polydispersity index (PDI)
Summary
The term ‘nanogel’ is defined as the nanosized particles formed by a cross-linked polymer physically or chemically. It was first introduced by cross-linked bifunctional networks of a polyion and a non-ionic polymer for the delivery of polynucleotides [1]. Nanogels have several characteristics that contribute to their effectiveness as a delivery system. Anticancer drugs and proteins are excellent for administration via chemically cross-linked or physically constructed nanogel systems because they have severe side effects, a short circulation half-time, and are degradable by enzymes [6,7,8]
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