Abstract
Objective: Chlorpheneramine maleate is a first-generation antihistamine drug used in the treatment of allergic conditions like rhinitis, urticaria, and cough cold, etc. In present work, the challenge has been made to develop an orally disintegrating tablet of chlorpheneramine maleate with an increase in bioavailability and patient compliance.
 Methods: The sublimation technique was used to prepare orally disintegrating tablets. Porous tablet prepared after sublimation of camphor at 60 °C in a hot air oven for 60 min. In the research work, 32full factorial design used to find out the effect of two variables like the amount of Crospovidone and Croscarmellose sodium.
 Results: All prepared formulations were analyzed for various parameters. DSC of pure drug and optimized formulation A (9) showed purity of sample and compatibility of all ingredients with each other. In FTIR study of pure drug and optimized formulation A (9) no major shifts were seen. An optimized formulation (A9) was found to have good hardness (3.2 kg/cm2), friability (<1%), disintegration time (26 s), % drug release (99.77 %) within 6 min.
 Conclusion: The result obtained showed that orally disintegrating tablet of chlorpheneramine maleate enhances dissolution rate, improves bioavailability which will improve patient compliance.
Highlights
The drug can be delivered to the systemic circulation by various routes of administration but among them, the oral route of drug delivery is more common
The result obtained showed that orally disintegrating tablet of chlorpheneramine maleate enhances dissolution rate, improves bioavailability which will improve patient compliance
Many patients face problems in swallowing tablet dosage form, to overcome this problem tablets are made that disintegrate in saliva before swallowing
Summary
The drug can be delivered to the systemic circulation by various routes of administration but among them, the oral route of drug delivery is more common. Oral drug delivery provides advantages of selfmedication, ease of administration, harmless [1, 2]. Disintegrating tablets avoid the first-pass metabolism of the drug as absorption takes place through mouth, pharynx, and esophagus as saliva passes down into the stomach. In such cases, the bioavailability of the drug gets increases and improves patient compliance [4,5,6]. Improvement in dissolution rate, accurate dosing, avoid suffocation due to physical obstruction, good mouthfeel, no need of water are the advantages of orally disintegrating tablets that increase acceptance criteria of the patient to use these dosage form
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