Abstract
Objectives: Tea tree oil (TTO) and Eucalyptus oil (EO) are essential oils derived from the leaves and terminal branches of Melaleuca alternifolia and Eucalyptus globulus. Both oils have narrative topical antifungal agents. Niosomal vesicles were chosen for Tea tree and EO dispersion in this investigation because of their ability to protect enclosed drugs, reduce drug dose amount, target drug delivery, increase residence time and penetration. Methods: TTO and EO containing niosomes were made using a modified thin-film hydration process and Carbopol 934 as a gelling agent to produce a smooth antifungal niosomal gel. Results: TTO and EO entrapment efficiency was found to be 84.89±0.19% and 86.86±0.57%, respectively, and percent cumulative drug diffusion of TTO and EO was found to be 84.21% and 85.22% in the prepared optimized batch [N9]. Transmission electron microscopy revealed vesicular, spherical particles in the nano range with a smooth surface. The optimum batch [N9] of niosomal gel was made with 1% w/w carbopol 934. TTO 84.9% and EO 86.89%, respectively, were found to have prolonged drug release in an in vitro release investigation utilizing the dialysis bag method. The G9 batch niosomal gel was found to be stable by performing an accelerated stability study for 3 months. Conclusion: It was concluded that the best formulation batch G9 shows better-sustained release, enhanced residence time, and stability.
Highlights
Skin infections are common and often offer treatment obstacles for practitioners due to increased concerns about multidrug-resistant bacteria, viral, and fungal strains. This is mostly due to their association with a wide range of diseases, ranging from minor skin and soft tissue infections to life-threatening systemic sepsis and meningitis
Clear transparent gels have been generally recognized in both cosmetics and pharmaceuticals as a topical preparation
Transparent gels have become more popular in cosmetics and pharmaceutical preparations among the principal category of semisolid preparations
Summary
Skin infections are common and often offer treatment obstacles for practitioners due to increased concerns about multidrug-resistant bacteria, viral, and fungal strains. This is mostly due to their association with a wide range of diseases, ranging from minor skin and soft tissue infections to life-threatening systemic sepsis and meningitis. Delivery of drugs to the skin is an effective and targeted therapy for local dermatological disorders This route of drug delivery has gained popularity because it avoids firstpass effects, gastrointestinal irritation, and metabolic degradation associated with oral administration. Due to the first past effect, only 25–45% of the orally administered dose reaches the blood circulation To avoid these disadvantages, the gel portions have been proposed as a topical application. Gels are defined as a “semi-solid system in which a liquid phase is constrained within a polymeric matrix in which a high degree of physical and chemical cross-linking is introduced [5,6,7,8,9,10,11,12]
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More From: Asian Journal of Pharmaceutical and Clinical Research
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