Abstract
and side effects. So the objective of the present research work is to reduce the side effects, Topical administration of drug is better for local action and the efficiency of the topically administered drug is increased with vesicles like Liposomes. Liposomes were prepared by rotator evaporation method and optimized on the basis of average vesicle size, % drug entrapment and polydispersity index. The optimized formulation was further encorpoated with gel base (carbapol gel) and characterized for their viscosity, extrudability, spreadability and drug release study. The NSAIDs is mainly used for the treatment of rheumatoid arthritis and osteoarthritis. Sulfasalazine is non steroidal anti inflammatory drug with analgesic, antipyretic and anti inflammatory activity and it is commonly used in the treatment of acute mild to moderate pain, as well as inflammation of the joints caused by certain type of rheumatoid arthritis. The sulfasalazine drug has less bioavailability(10-30%), more dose frequency dose frequency, increase the bioavailability and therapheutic efficacy. So sulfasalazine is chosen for development of liposome preparation.
 Keywords: Liposomes, rheumatoid arthritis, sulfasalazine
Highlights
Sulfasalazine is in the disease-modifying antirheumatic drugs (DMARDs) family of medications
Liposomes were prepared by rotator evaporation method given by Touitou et al, 2000 with slight modification in which drug was dissolved in methanol to give a concentration of 1.0% w/v of drug solution
In vitro drug release from liposomes was carried out using Frenze diffusion cell method and found 96.65±3.2% in 12 hr
Summary
Sulfasalazine is in the disease-modifying antirheumatic drugs (DMARDs) family of medications. The need for sustained delivery of sulfasalazine is further justified due to the requirement of maintaining un-fluctuating plasma concentrations for the effective management of Antiinflammatory drug. In such conditions transdermal drug delivery remains the most favored mode of administration where the hepatic metabolism of drug can be bypassed. Stratum corneum forms the most formidable barrier for the penetration of drug through skin. Liposome is reported to have the potential of overcoming the stratum corneum barrier and enhance the permeability of drug through the skin.[1,2,3,4]
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