Formulation, Development and Evaluation of Invasomes Loaded Clotrimazole Gel for Fungal Treatment

Abstract

The transdermal route is an important pathway for localized or systemic effects. The stratum corneum, the outer layer of the skin, is an essential skin permeation barrier for many drugs. To overcome this barrier, several techniques have been developed, including the use of the vehicle and nanocarriers to improve drug penetration. Recently, different types of nanocarriers have been designed to improve the dermal and transdermal delivery of medicines like ‘INVASOME’. We made clotrimazole loaded invasome gel which is used in fungal treatment. The procedure used in formulation of invasomal gel is mechanical dispersion method. This preparation is evaluate by many parameters they are appearance, spreadability, solubility, in vitro drug diffusion. And also discuss application of invasome.