Abstract
The present invention was aimed to formulate and evaluate Lafutidine gastro retentive films. The films were prepared by solvent casting technique using different film forming polymers like HPMC and Ethyl cellulose. PEG 400 used as a plastsizer. The prepared films were evaluated for number of parameters like Physical appearance, Weight variation, Thickness, Folding endurance, Tensile strength, unfolding behavior, floating properties, drug content and In vitro drug release studies. From the trial batches the best release for gastroretentive film was shown by formulation T5 (Ethyl cellulose and PEG 400). Formulation T5 exhibited good appearance, better mechanical strength with acceptable flexibility. Also, formulation T5 was given more than 90 % drug released after 12 hr and 97.56 % Drug content. For optimization of formulation, 32 factorial design was applied by taking Ethyl cellulose and PEG 400 as an independent variables. Drug release at 8 hour and folding endurance selected as dependent variables. Based on drug release study, L8 batch found most satisfactory in all formulation and the effect of Ethyl cellulose and PEG 400 found significant. L8 batch found stable during stability study.
 Key words: Lafutidine, Floating Films, Ethyl Cellulose.
Highlights
1.1 Introduction of Drug Delivery System1.1.1 Gastro retentive Dosage Form (GRDF): [1, 2]A few troubles are looked in structuring continued discharge and controlled discharge frameworks for better assimilation and upgraded bioavailability
Expandable gastroretentive measurements shapes (GRDFs) have been intended for as far back as 3 decades. They were initially made for conceivable veterinary utilize, yet later the structure was altered for improved medication treatment in people. These GRDFs are effortlessly gulped and achieve an altogether bigger size in the stomach because of swelling or unfurling forms that drag out their gastric maintenance time (GRT)
Peptic ulcers are sores that develop in the lining of the stomach, lower esophagus, or small intestine
Summary
A few troubles are looked in structuring continued discharge and controlled discharge frameworks for better assimilation and upgraded bioavailability. They were initially made for conceivable veterinary utilize, yet later the structure was altered for improved medication treatment in people These GRDFs are effortlessly gulped and achieve an altogether bigger size in the stomach because of swelling or unfurling forms that drag out their gastric maintenance time (GRT). A last little frame empowering clearing following medication discharge from the gadget In this manner, gastro retentivity is enhanced by the blend of considerable measurement with high unbending nature of dose shape to withstand peristalsis and mechanical contractility of the stomach. Upon landing in the acidic condition of the stomach, a trade of chloride and bicarbonate particles occurs Because of this response carbon dioxide was discharged and caught in the film along these lines conveying dots towards the highest point of gastric substance and creating a drifting layer of sap dabs rather than the uncoated dabs, which will sink rapidly. Round polymeric microsponges likewise alluded to as "microballoons" have been readied
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